Thanks to the guys over at Movieweb we've got a nice little The Amazing Spider-Man 2 spoiler, concerning the fate of Peter Parker's parents. Obviously if you like your Spidey adventures spoiler free, you should proceed with caution from here on in.
OK let's continue.
At the beginning of The Amazing Spider-Man a young Peter Parker has to flee his house after his father's study was ransacked. He goes to stay with Uncle Ben, only to discover later that his parents had been killed in a plane crash. We've now learned that the sequel is going to delve a bit deeper into his parent's storyline and show flashbacks of what happened to them.
We will see a flashback to the death of Richard and Mary Parker (Campbell Scott and Embeth Davidtz). More of the mystery is revealed, as we witness Mary getting shot on a plane, which causes the plane to go down in a crash, killing both Peter's mom and dad.
It's not a great deal to go on, but it does suggest that The Amazing Spider-Man 2 storyline is going to explore Richard and Mary's secret careers as CIA operatives and perhaps, further down the line, their confrontation with Albert Malik, the third Red Skull.