Fox has bought the movie rights to the Magic: the Gathering franchise with the intention of launching a movie series in the tradition of the Harry Potter and Lord of the Rings movies. I've been waiting for something like this to happen, and considering how much the franchise as a whole has developed in the last few years, I'm almost prepared to believe the pitch Fox gave Hasbro (who owns Wizard of the Coast, and thereby the MtG franchise) was as instrumental to the deal as the amount of money involved.
Short history lesson. MtG, the trading card game started 20 years ago. Since then, it has grown into a franchise of computer games, roleplaying games, web series, novels, comic books and more. The game is currently releasing four expansions a year, plus an extra (casual) set of cards for alternative formats of playing. Gaming stores hosts weekly tournaments each friday (called Friday Night Magic), a prerelease and release event for each new expansion set, and Game day events where players test their decks against each other. There's multiple formats of play, and they try to make cards and sets to be inclusive of both number crunchers and fantasy/mythology fans. Each new block of expansions (a block usually consists of three expansion sets) has a story of its own, and often introduces a new universe (called plane) to play around in. The collection of planes in MtG is called the Multiverse, and the select few with the ability to travel between the planes are called planeswalkers. In addition to the novels and comics set in the different planes of the multiverse, the MtG site releases a weekly column that explores the stories within the game expansions themselves (there used to be an additional column as well named Savor the Flavor, that read more like a history book. Unfortunately it's currently on an indefinite hiatus). In conclusion, if we add all these up, there's not exactly a lack of potential stories to tell in a movie franchise. For scope, think about Narnia. Through the Narnia series, we see its creation up to its destruction several millenia later. It's a long history of heroes, villains, entire races that die out and is replaced. Cities grow and crumble, hills becomes mountains, brooks become rivers. It's huge. The multiverse of MtG on the other hand, has several such planes, each with history books worth of lore. The only question is where to begin.
Thanks to there being Planeswalkers around to travel between planes, a few of them will probably show up. It's even likely that a group of them might turn out to be the main characters.
Sorin Markov is among the oldest of the planeswalkers, a vampire from the plane of Innistrad. He's notable for saving the humans of his home plane from his own people (for practical reasons. The vampires, werewolves and zombies of Innistrad were almost hunting the humans to extinction, which would have left the monsters without their main source of nourishment. Of course, his people didn't quite see it that way), and for sealing away the monstrous god-like Eldrazi on the plane of Zendikar.
Chandra Nalaar is a hotheaded thief and a fire mage. She joins Sorin as he attempts to reseal the prison holding the Eldrazi. She's also a treasure hunter of some repute. She's notable for stealing the Dragon Scroll from the Sanctum of Stars, only to be pursued by the mind sculpting planeswalker Jace Beleren.
Jace Beleren is a scholar, notable for his intelligence and penchant for incredibly bad decisions. He's been involved with most of the other planeswalkers at some point or another, and might be a good choice for main character, or at least as the knowledgeable supporting character.
Garruk Wildspeaker is an orphan left to his own devices in the jungles of his home plane (currently unnamed). Think of a cross between Mowgli of the Jungle Book and Conan the Barbarian, and that's pretty much where he's at. After the necromancer Liliana Vess killed one of his beasts, he flew into a rage and attacked her, only to be cursed with black magic. Since then he's been hunting her down, trying to force a cure out of her before the magic overtakes him completely (the hunt led him to her ex-boyfriend Jace, who in turn sent him after her to Sorins home plane of Innistrad).
Elspeth Tirel is not a hero. She keeps repeating this to herself, and yet keep ending up in situations where she has to lead an army of soldiers against some darkness or another. She's especially notable for her campaigns against Phyrexians, a collective of mechanic life of oil, metal and flesh.
Each of these five represent one of the five colors of mana: black, red, blue, green and white. If I were a betting man, I'd put money on at least two of these guys teaming up in one way or another. Possibly against one of the more villainious planeswalkers out there.