A recent report from New York Daily News says the actor has been contacted by Marvel in order to reprise his role as the Daywalker. The rights for Blade has been returned back to Marvel, since a movie hasn't been made in quite some time.
Also, the actor seems more than fit to come back into action and, hopefully, participate in a better movie than Blade 3.
But, then again, this is just a rumor so it should be taken with a pinch(or more) of salt. Especially since Marvel is not known for making anything else than child-friendly movies (and, if we are to watch the first two Blade films...)