Speaking with Yahoo today, Oscar Isaac spoke about bringing the evil mutant to life:
It’ll be a mix [of practical and digital]. I haven’t had a script so I haven’t had a chance to look through the script and see what the exact requirements are, but I think it’ll be a mixture of physical, aided with some robotic technology.
So that's pretty cool. I'm assuming his face will be majority practical, with a little bit of digital (the way Voldemort was entirely makeup except his nose). Speaking further on the topic;
After we finish here I’m heading to do a head cast [for ‘X-Men: Apocalypse’], which they do often. You spend 3-4 hours with them putting plaster all over your head and they get a sense of what your face is like and what shape your head is, so they can start figuring out the costume and the make up and all that stuff, which is pretty fun.
So his head will be bigger, according to this, but we don't know how much of it will be digital. Hopefully not too much, because I still like seeing practicality in movies. I assume the rest of the body will be primarily digital because of what he said in another interview:
The costume hasn’t been figured out yet, but one of his major powers is being able to change all the molecules in his body. So I’ll be changing all the molecules in my body… It’s gonna be a lot of fun.
If he's going to be changing his appearance that much, they might as well make it digital. I don't mind too much as long as they don't screw it up too much.
So what are your thoughts on [X-Men: Apocalypse](movie:1194267)?