After discovering a foreign city that is related to his resurrection, Coulson and his team destroyed it before the forces of Hydra could claim his secrets, eliminating the wicked Whitehall (Reed Diamond) in the process. But new threats have arisen for the world, including the father of Skye, Lime (Kyle McLachlan), which now looks for remuneration against Coulson;who stealed his revenge against Whitehall; a disturbing alliance between the ex agent of S.H.I.E.L.D. Ward (Brett Dalton) and the Agent 33; the enigmatic Raina (Ruth Negga), that fights against her transformation in something inhuman for the alien Obelisk and looks for revenge;And Skye (Chole Bennet), which has developed mysterious new power of the Obelisk, but whose lack of experience with her new abilities might threaten the integrity with those whom it loves.
Meanwhile, Bobbi (Adrianne Palicki) and Mack (Henry Simmons) begin the following phase of a plan that seems to have serious repercussions for Coulson and his team, but they don't know that there is another mysterious force moving against them. And Hunter (Nick Blood) is forced to take the major decision of his life, Coulson will discover that his mission sees threatened by this striking movement. In the premiere of half of season, the team of Coulson must treat with the consequences of his war against Hydra while the striking revelations separate them, and Hydra does a dangerous movement that a traitor might imply in the middle of S.H.I.E.L.D. Agents of S.H.I.E.L.D. 2×11 - Epidemic.
It's also confirmed that Adrianne Palicki is now a regular character.