In most every movie or TV show we've seen where someone is highly intellectual or has a really high IQ they've shown signs of being some form of a Sociopath. Basically a Sociopath is a person who is capable of having feelings and understands that other people have feelings as well they just don't care that their actions are affecting others and when they start to understand that they are affecting other people they lash out in frustration, anger or become reclusive so they don't have to face or deal with these feelings. When we see this in our beloved characters we root for them to "learn to be human" in a way but that will never truly happen for them because they may be able to understand the makings of the universe, it's hard for them to even try to understand that there is a reaction emotionally toward everyone they know as well as themselves.
The most notorious, loved and well known of these characters has to be the amazing Sherlock Holmes. We definitely know he's brilliant in every way (though his drug addiction is questionable) but he fails to treat everyone around him with the normality and even respect they deserve. Like his relationship with Dr. Watson, Holmes shows his gratitude to him a lot but when it comes to actual affection and even kindness Holmes does next to nothing about it and almost loses Watson in every way a few times because of it. When Holmes does have moments of actual clarity and expresses his happiness for having Watson as a friend even Watson seems to question if there's some sort of ulterior motive or if he's having a lapse from his drug addiction, which is really sad.
There's also Holmes' actions toward the supposed love of his life Irene Adler, along with her actions toward him. In my opinion they're both Sociopaths which is really inconvenient for them both considering they really do care about each other but are both too preoccupied with their own agendas and needs that they fail to have a "real" relationship. They essentially just keep dancing around each other and hurting one another (or themselves) to make sure the other is safe but also at a distance so that neither of them can get too emotionally close to one another. In the end they kind of "fall into each other" every once in a while to make their emotional states "evened out" so they can start the whole game all over again.
Another Sociopath but much less dramatic and dark character is Sheldon Cooper from the Big Band Theory. From the very beginning of the show he's been very goal oriented in fulfilling his own needs at the cost of others, mainly Leonard Hoffsteader. In the first few seasons of the show the writers of the show have been "developing" his social and emotional state where he goes from not knowing how to have really any interaction with people (other than correcting them in everything) to having a girlfriend where he still doesn't have the need for physical contact but is definitely in the midst of getting there.
Now in its 8th season Sheldon is still a bit of a robot at times but his social interactions have become more fluent without the help of his friends. But there have also been a few times where he throws everything to the wind and just does what he wants without caring how everyone around him will feel. like at the end of season 7 he decides to leave on a train for as long as he wishes because things in his life have gotten so "out of control" that he wants nothing to do with it anymore for the time being. By the time season 8 comes around he has formed somewhat of a plan to get in control again but immediately tries to leave again at the sight of Penny having cut her hair extremely short and obviously can't do anything about it. I believe Sheldon will forever burdened with disassociation though because like all mental illnesses there is no true cure or full recovery from it.
My third and final example of a screen Sociopath is the mass killer I'm sure we all know and love is Dexter Morgan from Showtime's Dexter. I think this is one of the only shows that actually admits or explains that their main character actually is a Sociopath. In the first and second seasons in a few of Dexter's flash backs you hear his adopted mom asking his adopted father Harry to get him tested for behavioral disorders and things like that and even though Harry says yes to having him tested he helps Dexter "cheat" by telling him that whatever he thinks is the right answer is wrong so say the opposite unless he wants to be taken away forever for being a "monster".
And because Harry kept calling him a monster until he was an adult made him even more distant and disassociated from everyone around him even though he did things that normal people would do he never had his heart in it, so to speak so that his horrible actions could be kept safe from the world. But of course as the show goes on he actually starts to get "in touch" with his feelings by way of his girlfriend and being forced to go into Narcotics Anonymous to get out of everyone finding out his secret but ends up giving him a wake up call that he really can feel things even though he's a "monster" on the inside. He even has a child of his own and is forced to go through all the pains and joys of being a father but still has the blockage and mentality that he can never be a fully functional person and gets very angry about that which is the main emotion most Sociopaths feel through their lives.
I know there are most likely countless more people that we can think of and label a Sociopath but these guys seemed to be the ones that popped out the most. Have any more examples of what makes these guys Sociopaths or even better characters that show this illness better? I personally love a good Sociopath every now and then because it might be nice to not feel anything for at least a little bit when life is so crazy, you know?