I know this might be sort of a cliche article. And I'm pretty sure most of you have already read like five or ten different versions of this countdown already. But I want to put my opinion out there on who I think Spider-man should fight in his first solo movie with Marvel.
Scorpion is definitely not Spider-mans strongest villain. But he might be just what Marvel is looking at for Spider-mans first villain. He's can't exactly be taken serious enough like Venom or Carnage. And since Marvel said they are trying to make Spider-mans debut more comedy than drama, Scorpion would fit perfectly.
Like Scorpion, Shocker isn't the most popular Spidey villain, but he'd be perfect for Spider-mans new movie. He's proven to be more than enough for Spider-man to handle on numerous occasions, so the threat is there. And he's the perfect villain for a more comedic Spider-man movie. Unlike Venom or Carnage who instantly bring a sense of seriousness and would immediately make the movie darker.
Mysterio is a very underrated Spider-man villain in my opinion. Unlike the other two, he can put up with Spider-man physically and definitely mentally. He has caused Spider-man to rethink his sanity more than once. And his traditional look would be more than enough for Spidey to pick at in the movie. He just looks like a villain you'd see in a comical Spider-man movie.