1. King of The Hill 1997-2010
After declining ratings, Fox eventually decided to cancel the show, with one of their major reasons being to make room for the Family Guy spin-off series The Cleveland Show. Was the third longest-running American animated television series after South Park and The Simpsons.
2. Futurama 1999-2013
The first and foremost cause of FOX refusing to order new episodes after four production seasons is attributed to the price of the show and its decreasing popularity. Despite Futurama's pilot episode, "Space Pilot 3000", being the most watched pilot episode on FOX when it aired, the show had been decreasing slowly in popularity over time, and FOX was disappointed in the show, which they had assumed could gain a popularity like their other show, The Simpsons, and even within FOX, arguments arose regarding whether they had kept Futurama alive for too long.
3. Beavis and Butthead
Beavis and Butt-head aired for 5 seasons and had over 200 episodes.At some point, there was a dispute between Mike Judge and MTV over money and rights issues. There was a split.Essentially MTV stole the character DARIA and made a spin-off cartoon 1997. Mike Judge had nothing to do with the cartoon and received no money for his intellectual property.
4. Cleaveland show
After four seasons on the air, Fox has canceled The Cleveland Show, according to animation site Cartoon Brew. Since premiering to strong ratings in the fall of 2009, the Family Guy spin-off has seen its viewership gradually decrease over the last four years (just like TV in general has) and ratings prognosticators have been expecting the cancellation.
5. Daria 1997-2002
There was just enough distance from the grunge era to give Daria some perspective on its anti-social main character.